As an aesthetic injector venturing into new regenerative frontiers, polynucleotides might just become your next must-have in the clinic. If the buzz about “salmon sperm” and DNA-based skin boosters hasn’t reached you yet, get ready to discover a treatment that’s delivering real science, real results, and real excitement worldwide.
What Are Polynucleotides?
Polynucleotides are essentially highly purified DNA fragments, most often sourced from the sperm of fish like trout or salmon. It may sound quirky (and conversation-worthy!), but this ingredient has decades of evidence behind it—from accelerating wound healing in burns to revitalizing aging skin. Today, modern extraction techniques mean you get a safe, consistent product every time, raising the bar for quality in regenerative medicine.
Why fish DNA? The answer is simple: freshness, purity, and renewability. These fragments are clean, potent, and readily accepted by your body for natural tissue repair—no weird side effects, no ethical quandaries, just pure science.
How Do Polynucleotides Work?
When injected into the skin in tiny droplets, polynucleotides act as a supercharged hydrator AND a bioregenerative stimulator. First, they bind water for an instant plumping effect. But their real magic starts at the cellular level—these DNA fragments are broken down, activating your fibroblasts through key receptors. The cascade that follows means more collagen, more elastin, better skin tone, enhanced texture, and a visible “glow” that’s hard to match. ✨
Clinical studies and real-world results highlight improvements in tough areas like under eyes, acne scars, and even stubborn conditions like rosacea. Less fine lines, more resilience, and healthier pigmentation—expect to see happier, more confident clients after every round.
Injecting Polynucleotides: Tips & Tricks
Disclaimer: Please note that the injection of polynucleotides is not within the legal scope of practice in the United States. The following information is for educational purposes regarding international aesthetic practices.
You’ll usually inject polynucleotides through a grid of microboluses in the dermis. The rule: higher concentration, more effect—and more stinging! Go gentler around the eyes and sensitive zones. Three sessions spaced three to four weeks apart deliver the most noticeable transformation. And yes, you can synergize with other regenerative modalities like exosomes for even better outcomes.
In places where injectable use is restricted, topical polynucleotide serums—with smaller molecule size—can be paired with microneedling to deliver benefits right where they’re needed most.
What’s Next?
With FDA approval rumored to be just months away, you’ll want to stay informed and ready. Polynucleotides offer a smart, evidence-based answer for clients craving natural, regenerative results—making you a leader in honest, science-driven aesthetic care. The shift from fillers to true skin regeneration is here. Are you ready to ride the wave?
Check out the full conversation with Dr. Steven Land